1. What is the difference between turmeric, curcuma longa and curcumin?
Curcumin is the principal curcuminoid found in turmeric. Turmeric is a rhizome with the botanical name “curcuma longa.” The curcuminoid curcumin is considered its most active component. Other curcuminoids present in turmeric rhizomes are demethoxycurcumin and bis-demethoxycurcumin.
2. What is the difference between curcuma longa (curcumin) extract and CAVACURMIN®?
Curcuma longa or turmeric extract is usually standardized to 95% curcuminoids consisting of about 65-80% curcumin,15-20% demethoxycurcumin and 2-5% bis-demethoxycurcumin.
CAVACURMIN® is a physical mixture of gamma-cyclodextrin and a 95% turmeric (curcuma longa) extract (not just curcumin). Gamma-cyclodextrin is a non-allergenic, vegetarian oligosaccharide used as hydrophilic carrier to improve the bioavailability of the water-insoluble curcuminoids, especially curcumin, by a factor greater than 40.
3. How is CAVACURMIN® different from other bioavailable curcumin products?
CAVACURMIN® consists only of curcuminoids and a safe hydrophilic carrier gamma-cyclodextrin. CAVAMAX® W8 gamma-cyclodextrin is a non-allergenic, vegetarian oligosaccharide.
CAVACURMIN® clinically demonstrated a bioavailability that was more than 40 times better than standard 95% turmeric (curcuma longa) extract and exhibited significantly higher relative absorption when compared to other leading bioavailable commercial curcumin products. The bioavailability of CAVACURMIN® was assessed in a double-blind, cross-over human study comparing our product not only with a standard but also with the two leading competitor formulations. The study was conducted with a verifiable low-fat diet to exclude the effect of fat/oil on the absorption of curcumin.
4. What pre-clinical and clinical studies have been done?
- An in vivo bioavailability study in a rodent model (conducted in Canada, 2009):
Plasma curcumin concentrations (0-4 hours) of rats were recorded after oral gavage of one dose of CAVACURMIN®. Animals that received CAVACURMIN® showed a 10 to 20 times higher amount of total curcuminoids in their blood plasma, expressed as the sum of free curcumin and its metabolites, than animals that received a commercial supplement product or pure 95% turmeric (curcuma longa) extract powder
- An in vitro bioavailability in a (human) Caco-2 model (conducted in Germany, 2011):
The dissolution profile in simulated intestinal fluid (SIF, 0.5% SDS) followed by the uptake of Caco-2 cells (human gut cell model) was investigated. CAVACURMIN® was up to five times more efficiently dissolved compared to three leading commercial curcumin supplement products or 95% turmeric (curcuma longa) extract powder itself. The uptake of Caco-2 cells was up to 10 times higher than for other leading commercial curcumin formulations or 95% turmeric (curcuma longa) extract powder itself. These results clearly underline the significant increase in bioavailability of curcumin in a gamma-cyclodextrin-based formulation.
- Human bioavailability in a clinical study (conducted in the US, 2013):
In a clinical setting, the relative absorption of CAVACURMIN® was compared to standard 95% turmeric (curcuma longa) extract and two leading commercial products claiming to have enhanced bioavailability. The results showed that CAVACURMIN® was around 40 times more efficiently absorbed compared to curcumin extract powder itself and at least 4.4 times better than the next-best commercial curcumin formulation in this clinical study. For more details, please see tab “Scientific Evidence"
5. Is CAVACURMIN® tested for heavy metals?
Every batch of CAVACURMIN® produced is tested at an external lab in the US for heavy metals including lead, arsenic, cadmium and mercury.
6. Is CAVACURMIN® allergen-free
Yes, CAVACURMIN® is free of allergens.1
7. Is CAVACURMIN® halal?
Yes, CAVACURMIN® is halal.
8. Is CAVACURMIN® kosher?
Yes, CAVACURMIN® is kosher.
9. What are the solvents used in the manufacture of CAVACURMIN®?
The raw material CAVAMAX® W8 gamma-cyclodextrin is manufactured from starch (of purely vegetable origin) using an enzyme of microbial origin. No solvents are used in this process.
The 95% turmeric (curcuma longa) used for the production of CAVACURMIN® is a pure natural substance and derived by solvent extraction of dried turmeric rhizomes. The solvents used are ethyl acetate or acetone. Both are listed in the EU 2009/32 directive as an extraction solvent which may be used during the processing of raw materials, of foodstuffs, of food components or of food ingredients without any specific limitations.
CAVACURMIN® is manufactured in a special WACKER process using only water.
10. Can CAVACURMIN® be taken with any other medication?
To date, there is no scientific evidence to prove that curcumin interacts with any medication. Please consult your physician or healthcare professional before consuming any supplements, including CAVACURMIN®.
11. What is the recommend dosage for CAVACURMIN®?
The recommended daily dosage for CAVACURMIN® is 1 g/day. Please consult your physician or healthcare professional before consuming any supplements including CAVACURMIN®.
12. Is CAVACURMIN® safe?
Curcumin has been widely used for centuries and is a well-known substance used in the traditional Ayurvedic approach to nutrition. Modern science has provided a solid basis for such uses (please see “Beneficial Effects” section for more details) and current clinical trials make curcumin one of the best investigated natural compounds to date. A positive safety profile at doses of 8-10 grams has been published in several clinical studies. CAVACURMIN® has been investigated in a human bioavailability study (15 individuals) with a dosage of 2 grams per day showing no adverse effects. The curcumin blood plasma levels achieved in the study are comparable to blood plasma levels reported in scientific literature as being safe.
13. What is the shelf life of CAVACURMIN®?
24 months from the date of manufacture.
14. What is CAVACURMIN® good for?
Please see tab “Beneficial Effects”.
1According to 2003/89/EC and 2006/142/EC.