Supporting Heart Health

Many people are worried about high cholesterol levels, which are among the most important controllable risk factors for cardiovascular diseases. There is a popular trend toward food supplements that help to improve cardiovascular health, and strong market growth opportunities are predicted in this area in coming years. WACKER’s portfolio contains two different ingredients for promoting heart health: the nature-identical hydroxytyrosol HTEssence® and the highly bioavailable coenzyme Q10 CAVAQ10®.

Impact of LDL cholesterol on atherosclerosis

High LDL-cholesterol values are among the most important risk factors for coronary heart diseases and atherosclerosis. A clinical study has shown that LDL-cholesterol values can be significantly reduced by HTEssence® (Siefer et al., J Nutr Med Diet Care 2018, 4:025). HTEssence® is a nature-identical, highly pure hydroxytyrosol, that is produced in a patented process. Available as an odorless, water-soluble powder or liquid, it is suitable for use in functional foods and dietary supplements in various forms including tablets, capsules, energy bars and functional beverages.

Change in LDL Cholesterol After 4 Weeks

In the clinical trial, HTEssence® achieved a reduction of 8% in the LDL cholesterol level (-9.4 mg/dl) compared to the initial value. 29 healthy test persons were administered 30 mg of hydroxytyrosol daily for four weeks.


  • Significant reduction of LDL-cholesterol by 8% in human clinical trial
  • Clinical study results published by Siefer et al., J Nutr Med Diet Care 2018, 4:025
  • Exceptional antioxidant effect (ORAC value of 45,000 µmol TE/g)
  • Vegan
  • GRAS, no E number
  • High-purity with constant technical properties

Read on to find out how the advantages of HTEssence® can be combined with CAVAQ10®, another heart health product.

The coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble, vitamin-like substance. As a preferred antioxidant, it is claimed to have a positive effect on the cardiovascular system and support the optimum functioning of the heart muscle. CoQ10 biosynthesis decreases with age and the consequent deficits in tissues are associated with degenerative changes appearing in the course of aging. CoQ10 supplementation can help improve the efficiency of energy production in human heart tissue (Rosenfeldt et al., 2003).

Since CoQ10 is a fat-soluble substance, which is poorly absorbed, it is not readily bioavailable in many commercial products. With CAVAQ10®, WACKER offers a gamma-cyclodextrin complex whose bioavailability is 18-fold higher than that of conventional CoQ10 products. This value has been proven in a human clinical study (Terao et. al., 2006). It is a dry, free-flowing powder that is easily dispersible in aqueous systems and is suitable for administration in various forms - from tablets to beverages.


  • 18-fold increased bioavailability of CoQ10
  • Comes as a dry, free-flowing powder
  • Easily dispersible in aqueous systems
  • Vegan
  • No E number, no additives

You can find more information about CAVAQ10®’s superior bioavailability here.

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