CAVACURMIN®: Study Reveals Increased Metabolic Bioavailability of Tetrahydrocurcumin

Munich, May 06, 2021

A study recently published in the Journal of Functional Foods shows that ingestion of the curcumin-cyclodextrin complex CAVACURMIN® leads to an increased metabolic bioavailability of tetrahydrocurcumin. A large portion of supplemented curcumin is converted into tetrahydrocurcumin in the body. This metabolite is credited with anti-inflammatory and antioxidant properties. CAVACURMIN® is the only formulation on the market that demonstrably boosts the bioavailability of both curcumin and tetrahydrocurcumin.

Durch den Einschluss in Gammadextrin kann eine schwer lösliche Substanz wie Curcumin bis zu 40-mal effizienter vom menschlichen Körper aufgenommen werden, wie eine kürzlich durchgeführte klinische Studie belegt. Als rieselfähiges Pulver ist CAVACURMIN® besonders für den Einsatz in Tabletten, Kapseln und Powerriegeln oder Getränken geeignet
CAVACURMIN® is a high-bioavailability complex of curcumin extract and gamma-cyclodextrin. Curcumin is extracted from turmeric. (photo: WACKER)

Curcumin, the active compound in turmeric, is a powerful antioxidant that supports healthy aging and joint health, as has been demonstrated in various studies. As it is not water-soluble, curcumin is not readily absorbed in the human bloodstream. Its bioavailability can be boosted significantly with the aid of gamma-cyclodextrin. A study published in 2018 shows that the curcuminoids of WACKER’s cyclodextrin complex CAVACURMIN® are absorbed around 40 times more efficiently in the body than those of a standard curcumin extract (Purpura et al. 2018)1.

As part of a randomized double-blind study, it has now been shown that the metabolic bioavailability of tetrahydrocurcumin is also around 40 times higher following ingestion of CAVACURMIN® compared to a standard curcumin extract (Hundshammer et al. 2021)2.

Ingestion of the curcumin-cyclodextrin complex CAVACURMIN® leads to 40 times higher metabolic bioavailability of tetrahydrocurcumin (image: WACKER).

Tetrahydrocurcumin is a curcumin metabolite credited with additional health-promoting properties. The metabolic bioavailability gives the ratio of the in-vivo production of tetrahydrocurcumin to the absorbed amount of curcumin. Another finding of the long-term study is that, after only four weeks, daily ingestion of CAVACURMIN® (approx. 340 milligrams curcumin each time) leads to a consistently high blood concentration of curcumin and tetrahydrocurcumin. This effect can be measured after 12 weeks as well. The long-term study furthermore confirmed very high tolerability of CAVACURMIN®.

CAVACURMIN® can be easily processed in food supplements, such as tablets, capsules and energy bars or functional beverages.


Using advanced biotech processes, WACKER BIOSOLUTIONS provides tailored, innovative solutions and products to the life-science sector – including pharmaceutical proteins, cyclodextrins and fermentation-generated cysteine. Its portfolio is also complemented by catalog chemicals, such as acetylacetone. The division focuses on developing customized solutions for growth sectors, such as food ingredients, pharmaceutical actives and agrochemicals.





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Inclusion in gammadextrin makes a hard-to-dissolve substance such as curcumin up to 40 times more absorbable by the human body, as shown in a recent clinical study. As a free-flowing powder, CAVACURMIN® is ideal for use in tablets, capsules, energy bars and beverages.

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Wacker Chemie AG
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Manuela Dollinger

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