Experience makes all the difference in isolating and purifying recombinant proteins. Our teams work in dedicated laboratories to develop processes for cell separation, refolding (where necessary), and subsequent product purification.

Efficient purification processes are the result of our employees’ experience, systematic selection of the chromatography media and filtration steps, and specification of chromatography parameters in direct liaison with the process development analytical team.

Our integrated approach and constant communication throughout the entire development phase ensure that the subsequent process scale-up and cGMP requirements are taken into account.

In addition, we call on our strategic partners to help out with special requirements.

Our services include:

• Development of the entire purification procedure from cell harvest to the final active ingredient
• Selection and optimization of a suitable cell harvesting method (centrifugation, separation, cross-flow filtration)
• Selection and optimization of the refolding procedure
• Design, selection and optimization of a suitable purification method (chromatography instructions, media and scale, and filtration steps)
• Process optimization in terms of yield and product quality
• Optimization of the purification process based on process- and product-specific contamination to increase product quality and safety
• Definition of key purification parameters
• Validation of the downstream process including life-time studies